Extracts of polyherbal formulations used in traditional Indian medicine for the treatment of diabetic chronic wounds have been found to posses ‘potent’ antibacterial and anti-inflammatory properties.
Researchers from Latvia and India set out to investigate the potential of crude hexane and ethanol extracts of polyherbal formulations Jathyadi Thailam and Jatyadi Ghritam (JT), which are also used in Indian traditional medicine for the treatment of fistula, fissure, eczema, and burn management.
The report, Antibacterial and anti-inflammatory potential of polyherbal formulation used in chronic wound healing, found that “extracts of JT formulations possess potent antibacterial and anti-inflammatory properties that could be involved in chronic wound healing activity and has the potential to be used as external add-on therapy in the management of multidrug-resistant bacterial infections at the wound.”
Led by Associate Professor Tatjana Tracevska from the University of Latvia, researchers found “the antibacterial activity of JT extracts was higher against Gram (+) bacteria, with the MICs varying from 1.95 to 62.5 mg/mL. Gram (-) bacteria were only susceptible to ethanol extracts of JT. Plant extracts were found to be the most active against the reference and clinical strains of MSSA, MRSA, and biofilm-forming S. epidermidis. JT extracts efficiently inhibited in a dose-dependent manner the mRNA expression and protein secretion of proinflammatory cytokines IL-6 and IL-1β, and chemokines MCP-1 and CXCL10 in LPS-challenged macrophages.”
The team behind the findings included researchers from the Latvian Biomedical Research and Study Centre and the AVP Research Foundation in India.