Researchers have identified new predictive biomarkers for diabetic foot ulcer, providing insights into its pathogenesis and diagnostic strategies.
The underlying mechanisms of the chronic inflammation which characterises diabetic foot ulcer remain unclear.
A new study by researchers in China aimed to identify plasma inflammatory biomarkers distinguishing diabetic foot patients from those with diabetes and healthy controls.
The team analysed 92 inflammation-related proteins in fasting plasma samples from each group. They identified MCP-4, SLAMF1, CD5, CSF-1, and FGF-5 as having “high diagnostic potential”.
The researchers, who are mostly based at the Department of Hand and Foot Microsurgery at the University of South China, concluded: “Functional enrichment analysis linked these proteins to inflammatory pathways (e.g., cytokine-cytokine receptor interaction) and macrophage activation.
“This study highlights MCP-4, SLAMF1, and CSF-1 as novel predictive biomarkers for diabetic foot, providing insights into its pathogenesis and diagnostic strategies.”
Read the study, Plasma Proteomics-Based Identification of Novel Predictive and Diagnostic Inflammatory Biomarkers for Diabetic Foot, here.
