‘Significant difference in healing’ reported following use of fish skin graft to treat diabetic foot ulcers

A randomised trial to evaluate the effect of omega-3-rich fish skin in the treatment of chronic, non-responsive diabetic foot ulcers has shown promising results.

The American, multicentre trial, which aimed to assess the number of closed wounds at 12 weeks, compared the effectiveness of fish skin graft compared to traditional treatment – collagen alginate dressing.

The second of three planned articles reports: “As of the time of this writing, 94 patients had completed the protocol. At 12-week follow-up, healing was achieved in 63.0% of index ulcers (29 of 46 patients) in the acellular fish skin graft group compared with 31.3% in the control group (15 of 48 patients) (P =.0036). In both groups, the mean time to healing was 7 weeks. The median number of applications of the fish skin graft to achieve healing was 6.”

The authors, led by Dr John C Lantis, from the Icahn School of Medicine, Mount Sinai Morningside and West Hospitals in New York, concluded: A clinically and statistically significant difference in healing was observed between patients treated with acellular fish skin graft and those treated with a collagen alginate dressing. The data support the completion of this prospective randomised trial.”

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